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The radioisotope, Lu-177 is emerging as an important radioisotope for treatment of the cancer such as breast, prostate, colon, and brain, with a longer half-life of 6.65 days. The Lu-177 can be produced by indirect Yb-176(n,γ) Yb-177→Lu-177 route which requires a chemical separation of Lu-177 from the target Yb-176 target atoms.The method of separation of Yb and Lu were used via Yb-176(n,γ) Yb-177→Lu-177 to produce no-carrier-added Lu-177. For this process, 10 mg of non-radioactive Yb2O3 and 10 µg of Lu2O3 were used in which radioactive labels of Yb and Lu were added to induce radioactivity (ratio Lu:Yb = 1:1000). Cementation process was performed for five similar experiments (three cementations in each experiment). Yb2O3 target material was translated into chloride, mixed twice with hydrochloric acid (HCl), sodium acetate (CH3COONa) and the selective extraction of Yb by sodium amalgam Na (Hg). HPGe detector GX1018 coupled with a multichannel analyser (MCA) (Canberra) was calibrated with Eu-152 source for analysis of Lu-177 in the presence of Yb. Gamma-ray peak of 208 keV for Lu-177 and 198 keV for Yb-169 were detected in the system. The activity of the third cementation process of radioactive Yb and Lu were found to be 2.06±0.05 Bq and 96.97±4.16 Bq which corresponds to 1.4 mg and 7.6 μg, respectively. After the cementation process, Yb target was extracted by distillation process. From the results obtained, the amount of the ytterbium was removed from the aqueous solution and the NCA Lu-177 was isolated in the solution. After the cementation process, high amount of Yb was observed. In conclusion, it is necessary to carry out optimization for better separation of Yb and Lu.
| Apply for student award at which level: | MSc |
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