Speaker
Description
Optical tweezers have long been used as a tool for manipulating micro- and nanoscale objects, with applications in biological systems and modelling colloidal crystal structures. Recently, optical tweezers have been incorporated into microfluidic chips for isolating single cells and force measurements. In this talk, we present a single-cell monitoring platform which uses holographic optical tweezers (HOT) to manipulate multiple cells simultaneously or biological specimens with irregular shapes within a microfluidic chip. Examples include fibrinogen microclots linked to long-covid symptoms or cardio myoblast spheroids. We discuss the trap generation methodology for irregular shapes, which traditionally cannot be trapped using single-beam geometries. Finally, we outline different imaging modalities integrated with the HOT system that we use for monitoring cellular properties under changing extracellular environments. This system could be used as a drug screening platform for informing dosage protocols for individual patients.
| Apply for student award at which level: | PhD |
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| Consent on use of personal information: Abstract Submission | Yes, I ACCEPT |